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Overall, many had meaningful weight loss, but some individual results varied, according to the Cleveland Clinic: "Those treated for obesity lost an average of 8.4% of body weight before discontinuation and regained an average of 0.5% one year later Those treated for type 2 diabetes lost an average of 4.4% of body weight before discontinuation and lost an additional 1.3% of body weight one year later In the obesity group, 55% gained weight in the year after discontinuation, while 45% kept losing or stayed the same In the diabetes group, 44% gained weight, while 56% kept losing or stayed the same" There were two primary issues that led to patients stopping the medication, which were cost or insurance coverage, and side effects

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These limitations underscore the need for longer-term, more detailed studies to fully understand semaglutides role in joint health and musculoskeletal outcomes