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The translocated cyt c hijacks histone chaperones such as suppressor of variegation, enhancer of zeste and trithorax (SET)/template-activating factor (TAF)-I, inhibiting the nucleosome assembly/disassembly activity and DNA repairing (Gonzlez-Arzola et al., 2015
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David Sinclair's lab at Harvard demonstrated that NAD+ restoration via NMN supplementation reversed age-related muscle degeneration and improved mitochondrial function in aged mice (Gomes et al., Cell, 2013)
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