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As background, the authors noted that the study had been prompted after incidents of aspiration under anesthesia were reported for patients using GLP-1 RA drugs for weight loss, despite usual fasting before the procedure

Causal pathways are yet to be fully understood but are considered likely to be multifactorial, including: immune modulation, chronic inflammation, insulin resistance and hormonal imbalance

Osmotic laxatives (macrogol) draw water into the bowel and are well-tolerated for long-term use, making them suitable for chronic GLP-1 therapy

It is primarily the stromal cells that produce extracellular matrix and form fibrotic scar tissue