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it should also be interpreted in the context of tumor cells adapting to microenvironmental conditions such as hypoxia, inflammatory stimuli, hormonal and growth factor signaling, and metabolic stress acting together to reinforce survival and progression programs ( Reactive oxygen species (ROS) are a group of oxidative molecules generated through processes such as electron leakage from the mitochondrial electron transport chain and the activity of NADPH oxidase family enzymes

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Importantly, long-term and follow-up trials are needed to assess their long-term efficacy and safety