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Adults were randomly assigned to receive 4 milligrams (mg), 9 mg, or 12 mg of retatrutide, or a placebo, in the form of a once-weekly injection
Comparisons With Other Diabetes Therapies Putting GLP1s in context with other antidiabetic agents offers additional insights: Thiazolidinediones (TZDs) are associated with increased fracture risk, especially in women SGLT2 inhibitors have raised concerns in some trials, particularly canagliflozin DPP-4 inhibitors appear largely neutral regarding skeletal effects Against this backdrop, GLP1s may have a neutral or possibly safer profile, though the data are not conclusive
Quite simply, take it with carbs
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