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Monoacylglycerol lipase: a novel potential therapeutic target and prognostic indicator for hepatocellular carcinoma
Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
Fasted-state administration maximizes bioavailability by eliminating dietary nicotinamide competition for NNMT binding sites
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