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doi: 10.1002/ptr.8193 15 GravandiMMAbdianSTahvilianMIranpanahAMoradiSZFakhriSet al

Reconstitution is performed in the laboratory using a suitable solvent such as bacteriostatic or sterile water, added slowly down the vial wall and allowed to dissolve without vigorous shaking

This is part of why B12 has a strong safety record, and it is also why levels sometimes need regular replenishment during active treatment