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Subcutaneous B12 administration, although promising in select cases such as congenital cobalamin disorders, lacks comprehensive comparative studies against IM and oral routes
This issue is particularly relevant in epithelial organs such as the kidney, where tubular cells are aligned along the nephron axis but are not necessarily in continuous plasma membrane contact
Also Gopal und Iwama (2007) proposed PEG to limit O 2 movement resulting in O 2 deficiency in roots, and therefore postulated that PEG might not be an ideal osmotic agent
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