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doi:10.1016/j.jocn.2026.111877
44 Excessive ROS can inhibit IRS1 activation by activating inflammation-related protein kinase C, inhibitor kappa B kinase (IKK), c-Jun N-terminal kinase (JNK), and p38 MAPK, thereby aggravating IR, 45 creating a vicious cycle
In addition, more mitochondria-produced ROS accumulate when inflammation causes oxidative stress
Weight-loss results vary based on the person, medication, and other health and lifestyle factors
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