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Subgroup analysis The cost-effectiveness analysis performed in patients not receiving SGLT-2 inhibitors at baseline resulted in increased mean life expectancy by 0.77 years and improved quality-adjusted life expectancy by 0.62 QALYs with semaglutide compared with placebo, similar to the outcomes observed in the full FLOW population (Table 2)
World Journal of Gastroenterology 20
The pre-sleep dose aligns with natural GH secretion patterns, while the fasted morning dose takes advantage of low insulin levels, which can enhance GH release
Limitations of use: - It has not been studied in patients with a history of pancreatitis
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