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CJC-1295 without DAC is more precisely described as tetrasubstituted GRF(1-29), a 29-amino-acid fragment of growth hormone releasing hormone carrying four substitutions (D-Ala at position 2, Gln at 8, Ala at 15 and Leu at 27)

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1,2 The IGFBPs may modulate the action of IGFs in several different ways: Inhibitory Model - IGFBPs prevent IGF/receptor association Enhancing Model - IGFBPs transport IGFs and facilitate binding with IGF receptors IGF Receptor-Independent Model - Product of direct IGFBPs/IGFBP receptor interaction Proteolytic Cleavage of IGFBP - Cleaved into lower affinity fragments which increases freely circulating, bioavailable IGF IGF-1 IGF-1 (Somatomedin C) is one of several growth factors necessary for normal human development