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Combined Approaches (Neelakantan et al., 2022): NNMT inhibition with reduced-calorie diet produced dramatic adiposity reduction in DIO mice, normalizing metabolic parameters and establishing a distinct gut microbiome
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However, further research using animal models is needed to evaluate the potential of B12 as an epidrug for in vivo modulation of peripheral biomarkers associated with persistent VCD in long COVID and to determine whether this contributes to neuroprotection
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