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The net medication-attributable GI event rate is roughly 25 to 30%, meaning about one in four people experience GI symptoms that would not have occurred without the medication
Your provider might also check for underlying factors that make weight loss more difficult, such as insulin resistance, thyroid dysfunction, or hormonal changes related to menopause
Moreover, although randomized designs mitigate healthy-user bias, participants enrolled in long-term cardiovascular outcome trials may represent a healthier, more adherent subset of patients, potentially limiting generalizability
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