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Insulin-like Growth Factor-1 (IGF-1), a hormone produced in the liver, is released in response to Human Growth Hormone 2
doi: 10.3389/fped.2019.00059 502 NishikaiMTomomatsuSHankinsRWTakagiSMiyachiKKosakaSet al
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This proposed mechanism has been directly validated in animal models where the surgically severed vagus nerve attenuated anxiety- and depression-like behaviors in mice after oral antibiotic administration, providing direct evidence for neuropsychiatric effects induced by antibiotics through the gutbrain axis (Joo et al., 2023)
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