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The simulation indicated that amlodipine preferentially bound to amino acids, including proline (Pro)420, glutamic acid (Glu)424, serine (Ser)109, aspartic acid (Asp)111, arginine (Arg)458, Glu-125, alanine (Ala)510, threonine (Thr)514, Asp-517, Thr-518, lysine (Lys)114, histidine (His)145, Arg-185, leucine (Leu)115, Glu-182, and Thr-518