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Studies 1 and 2, which enrolled a total of 418 patients, showed DUOBRII was consistently more effective than vehicle in achieving treatment success (primary endpoint at eight weeks), demonstrating statistically significant superiority by week four in study 1 and week two in study 2

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Cannabis affects the endocannabinoid system, influencing appetite, mood, pain perception, and gastrointestinal functionsystems that may overlap with Wegovy's mechanisms