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Beyond direct antioxidant activity, glutathione functions through several enzymatic systems central to detoxification and redox control, including glutathione-S-transferases for conjugation reactions, glyoxylases, glutathione peroxidases and peroxiredoxins for peroxide reduction, and glutaredoxins for thiol-disulfide exchange
Indeed, a rise in IGF-1 levels have been observed in multiple studies of IGF-1R blockade, which is attributed to the reduction in IGF-1-mediated inhibition of GH secretion 26,40
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Ferroptosis in a sarcopenia model of senescence accelerated mouse prone 8 (SAMP8)
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