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In addition to the eyes, hair, skin, ovaries, heart, and arteries, including those leading into the heart, melanin is present in other organs and tissues, including the liver, inner ear, lung, connective tissues, spleen, kidney, testes, peritoneum, muscles, choroid, pineal gland, and, of course, the brain (dopaminergic and noradrenergic neurons, meninges covering the brain, and glial cells) (41, 89)

In some cases, the discontinuation of GLP-1 therapy can result in weight regain due to a rebound effect [43, 44]

It should not be used in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in those with multiple endocrine neoplasia syndrome type 2 (MEN 2)

More entrenched problems often require several weeks to months of consistent treatment plus rehab before the changes feel significant