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29,30 However, in the periodontitis model, we observed a fundamental reprogramming of GSH metabolism in BM neutrophil, with IFN-I signaling markedly upregulating the degradation-regulatory protein Chac2, which can in turn repressed the catalytic activity of Chac1, 38,39,40,69 resulting in substantial intracellular GSH accumulation

Aberrant DNA Methylation of P16, MGMT, and hMLH1 Genes in Combination with MTHFR C677T Genetic Polymorphism in gastric cancer