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Though the exact way semaglutide causes weight loss is unknown, the above changes appear to impact weight loss positively
Early in treatment, state signals such as gastrointestinal discomfort and enhanced satiety may predominate, manifesting as short-term reductions in liking or food avoidance
Blood Glucose and HbA1c Changes Observed in the Trial The 12 mg dose produced mean HbA1c reductions of approximately 2.2 percentage points (~24 mmol/mol) at 24 weeks, with some participants reaching HbA1c levels below the 48 mmol/mol diagnostic threshold for type 2 diabetes
J Pharm Sci 1995;84(5):627-633
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