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Under high glucose conditions, endothelial cells acquire the characteristics of fibroblasts, via endothelial-mesenchymal transition (EndMT)
They studied patients in SELECT for about 4 years, giving half of them Wegovy and half of them placebo
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45,46 As shown in Figure 2 , GLP-1RAs penetrate the blood-brain barrier and directly activate GLP-1 receptors in the hypothalamus, especially within the ARH nucleus, a key center for appetite regulation
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