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Personal or family history of auto-immune disease for instance, thyroid disease, vitiligo, type 1 diabetes, Sjogrens disease (dry mouth and other symptoms), Addisons disease
These, for example, include prodrug strategies, as seen in the case of OTC, which was designed to have improved bioavailability and stability (it is thought of being converted to cysteine intracellularly, which is then used for GSH synthesis) or NAC amide that has improved lipophilicity and cell permeability
In extreme cases it can even lead to death
The data reveals a concerning rapid adoption of these medications during the perinatal window
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