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The shedding is usually temporary, with regrowth occurring once weight stabilizes
Nevertheless, current evidence supports GLP-1 RAs and multi-agonist formulations as highly promising pharmacotherapies that address the complex, multifactorial pathophysiology of MASLD while simultaneously improving cardiometabolic comorbidities, positioning them as cornerstone treatments in the evolving therapeutic landscape for this prevalent and burdensome disease
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In beta-3-adrenergic-receptor knockout mice, the chronic body-weight and lipolysis changes observed in wild-type controls were not reproduced
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