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or tirzepatide, the active ingredient in Zepbound, White notes

As the primary source of reducing equivalents, NADPH is primarily produced by glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase in the pentose phosphate pathway (PPP)

The injectable requires subcutaneous injection, starting at a low dose of 0.25 mg weekly for the first four weeks and gradually increasing the dosage monthly

Dr Johnson and coauthors explained that emerging data suggest GLP1RA may also exert anti-inflammatory effects beyond weight loss. They went on to add, As the prevalence of obesity rises in patients with [IBD], there is mounting interest in understanding the effect that GLP-1RAs have on IBD-associated outcomes. There were 580 patients with IBD (UC, n=322