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10.1186/s40779-018-0161-x 133 XiaoJ.LiX.GaoZ.MengF.LuJ.HouD.et al (2021)

Animal infusion models do show blunting with continuous exposure, which is expected for any GPCR agonist

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These little critters, in excess, can cause disruption to normal cellular function and can damage various parts of our cells (for our purposes cell membranes, mitochondria, & DNA of the sperm, egg, and other reproductive organ tissues)