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Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking CONTRAVE is a prescription weight-loss medicine that may help adults with obesity, or some adults who are overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off.
The mechanism is likely related to the metabolic changes, reduced caloric intake combined with the body adjusting to higher drug levels
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