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Route, food, metabolism, and product quality could all change how long the compound remains in the body

For a 70 kg individual, this translates to approximately 1.75-28 mg per dose, though standard therapeutic protocols use significantly lower daily doses

Many foods are fortified with artificial vitamin B12, such as non-dairy milks and cereals, but these are not always optimally absorbed, so vegans must still be proactive about making sure they are not becoming deficient

Because the reaction consumes both nicotinamide and a methyl donor, changes in NNMT expression may influence the availability of metabolites associated with NAD turnover and methylation balance