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In light of glucagons ability to increase glucose production, and the documented beneficial effects of glucagon signal inhibition for the treatment of type 2 diabetes, at first glance it seems counter-intuitive that glucagon could be used in unimolecular combinations with GLP-1 to treat obesity and type 2 diabetes [114]

Clinical data also indicate beneficial molecular effects of GLP-1 RAs, despite their potential to reduce muscle mass

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