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The diagnosis of adrenal insufficiency is established by the 24-hour corticotropin-stimulation test
Interestingly, His1-Gly2 of exendin-4 exhibited weaker density relative to the rest of the peptide in the cryo-EM map, and this is consistent with the enhanced flexibility observed for this region of the bound peptide in the simulations, likely due to Gly2, as glycine can destabilise -helical conformations
The efficacy of the supplement was particularly evident during the post-treatment phase, as illustrated in Graph 1
Psychiatry 170 , 102110 (2013)
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