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That three-part separation is deliberate and it's the legal architecture that governs how this model operates
Illustration created with BioRender.com
Indeed, GLP-1RAs have evolved over time such that the frequency of dosing has decreased from twice-daily (exenatide, BD) [65], to once-daily (liraglutide, lixisenatide) [66, 67] to once-weekly (dulaglutide, exenatide QW, semaglutide) [5, 6], suggesting a higher adherence potential for the longer-acting agents (Table 2)
However, discontinuation is common, and clinical trials have demonstrated significant weight regain following cessation
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