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The localization of FUNDC1 at ER-mitochondria contact sites (MAMs) and its role in integrating mitophagy, mitochondrial adaptation, and ER stress responses exemplify how spatial organization determines functional proteostasis outcomes

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Andrew Huberman: Which is really, for people listening, that's so important because a number of compounds that people take in supplement form don't cross the blood-brain barrier, or they get metabolized in ways that what's listed on the bottle almost becomes irrelevant for what your cells actually experience