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It has been indicated that administration of MSG can induce activation of glutamate receptors which triggers the intracellular Ca 2+ signaling pathway

GSH levels decrease with age and due to certain disease states e.g Type 2 Diabetes Mellitus, cardiovascular disease.(2) Oral NAC increases GSH levels by providing the liver with an increased supply of cysteine promoting an increase in GSH synthesis, and therefore reduce oxidative stress

Environmental Factors: While genetics plays a key role, environmental influences are pivotal, especially given the less-than-complete concordance in monozygotic twins

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