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10.1016/j.brainresrev.2009.05.005 Brain Res Rev

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If a glucagon-containing triple agonist can lower A1C by roughly 2% while also driving large weight loss, then the GLP-1 and GIP arms are clearly counterbalancing glucagons tendency to raise glucose

Ele atua de duas formas principais: estimulando a secreo de insulina pelo pncreas em resposta glicose e retardando o esvaziamento gstrico, prolongando a saciedade aps as refeies