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Food and Drug Administration (FDA)-approved for both T2D and obesity under the trade names Mounjaro and Zepbound, respectively, and is under investigation in MASLD
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Preclinical models indicate that GLP-1 receptor activation can influence the gut-brain axis as well as the hypothalamic-pituitary-adrenal (HPA) axis, with possible implications for stress regulation and energy homeostasis[11]
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