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225,226,227,228 Backbone modification The modification strategies used in first-generation NADs have focused on modification of the phosphate backbone, mainly using other types of groups to replace the non-bridging oxygen atoms in the phosphate backbone, such as phosphorothioate (PS), methyl phosphate, and boranophosphate
For those who dont consume animal foods, such as vegetarians and vegans, there are plant-based sources of vitamin B12 available, including nutritional yeast, fortified foods, cereals, mushrooms, and certain types of algae
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