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Science 339 , 819823 (2013)

Nausea (most common, especially during first 1 to 2 weeks of a new dose) Diarrhea or, just as often, constipation Vomiting (less common but more likely at 9 to 12 mg) Reduced appetite, food noise quieting down (this is the goal, not a side effect) Skin sensitivity (dysesthesia): tingling, prickly feeling, or sunburn-like skin

Research indicates that GLP-1 receptor activation can reduce the brain's response to high-calorie food cues, making it easier for subjects to resist processed snacks and sugary treats

Moreover, the underlying mechanism that slows digestion and sometimes causes reflux is precisely what helps patients feel full and eat less, driving sustainable success