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Conclusions The result of this meta-analysis demonstrates that compared to sitagliptin, GLP-1 analogues are more effective for glycemic control and weight loss, but have similar efficacy in reducing blood pressure and lipid parameters, however, GLP-1 analogues are associated with a higher incidence of gastrointestinal adverse events and a similar incidence of hypoglycemia compared to sitagliptin

In the UK, Ozempic is prescribed according to NICE guidelines (NG28) for type 2 diabetes management, typically when metformin and other treatments have not achieved adequate blood sugar control

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