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Hato SV, Khong A, de Vries IJM, Lesterhuis WJ (2014) Molecular pathways: the immunogenic effects of platinum-based chemotherapeutics

The substance is broadly safe in topical use at typical formulation concentrations of 0.05 to 0.2 percent

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Specifically, it upregulates genes involved in collagen synthesis (Types I, III, and V), decorin production (which regulates collagen fibril assembly), integrin and glycosaminoglycan synthesis, DNA repair enzymes, antioxidant defense systems (superoxide dismutase, glutathione), and stem cell markers