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In clinical studies, the increase was significant (approximately 181 micrograms per liter above baseline) but remained within physiological norms

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Based on the available information, the 2024 AHA Guideline for the Primary Prevention of Stroke recommends using GLP1RAs in patients with diabetes and high cardiovascular risk or established CVD and hemoglobin A1c 7% (Class of Recommendation 1, Level of Evidence A) [36]