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Its defining structural feature is the gamma-glutamyl linkage: the glutamate residue is joined through its side-chain carboxyl rather than the usual alpha-peptide bond, which makes the molecule resistant to most intracellular peptidases and means it is cleaved almost exclusively by gamma-glutamyl transpeptidase at the outer cell surface (Zhang, Forman and Choi, Methods in Enzymology, 2005)

TABLE 2 Pharmacologically underexploited metabolic peptidereceptor systems beyond incretins: native peptide pharmacology underdeveloped despite validated biology

Satellite cells show increased proliferation markers, extending their capacity

Epub 2017 Sep 10