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In a randomised controlled trial with overweight/obese people, once-weekly survodutide induced dose-dependent mean body-weight changes up to 14.9% for those assigned to the maximum dose of 4.8 mg, compared to 2.8% with placebo

Methods: A comprehensive literature review was conducted, analyzing recent advancements in GLP-1-based therapies, their mechanisms of action, and their clinical applications

247 Disruption of mitophagy may result in the accumulation or cytosolic release of damaged mtDNA, which functions as a damage-associated molecular pattern (DAMP) and activates inflammatory pathways involved in pancreatic necrosis and inflammation

Semaglutide fatigue and GLP-1 related fatigue can be addressed through proper nutrition, hydration, and electrolyte balance rather than additional supplements