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Epac activates the MAPK pathway, thereby promoting the activity of cyclin-dependent kinase 2 (CDK2) and CDK4, which in turn facilitate -cell differentiation and proliferation [35, 36] (Fig
Abstract Background Glucagon-like peptide-1 receptor agonists, originally developed for managing type 2 diabetes, have gained attention for their weight-reducing and broader biological effects
Mechanistic literature demonstrates that IGF-1 supports satellite cell activation, myogenic differentiation, and regenerative remodeling, which is why IGF-1-linked markers are routinely tracked in preclinical studies involving this combination [7]
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