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As intermediaries in the pharmaceutical supply chain, pharmacy benefit managers (PBMs) must consider how advertising may drive suboptimal utilization based on consumer demand rather than clinical evidence on safety and efficacy
This study used the Proportion of Days Covered (PDC) because it is more sensitive to capturing uncovered days compared to the Medication Possession Ratio
Some researchers use microdosing approaches to create even more gradual escalation
When objective testing is unavailable, therapeutic trials of bile acid sequestrants (such as colestyramine or colesevelam) may be considered, with symptomatic improvement supporting the diagnosis, though this approach has limitations in specificity
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