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A useful LMN includes the diagnosis (typically obesity with BMI documentation, or overweight with a weight-related condition), the medication name and prescribed dose, the medical reason the medication is necessary, and the prescriber's signature and credentials
Important: Semaglutide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2), and is not recommended during pregnancy, especially when used for weight management
Research examining the neural mechanisms has shown that Melanotan II microinjected into the nucleus accumbens significantly decreased both motivation to obtain food and total food consumption in operant and home cage paradigms
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