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10.1089/ars.2013.5607 162 KosselA.DakinH
As class B1 peptide agonists engage their receptors via a two-domain interaction, their efficacy for G protein-mediated signalling is influenced by multiple factors, including the nature of interactions with the ECD and TMD, contributing to both peptide affinity and how ligandreceptor interactions influence G protein binding, nucleotide exchange and G protein dissociation from the receptor
Nature 490 , 5560 (2012)
Sternberg P, Davidson PC, Jones DP, Hagen TM, Reed RL, et al
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