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Due to their imidazole ring, they possess unique acid-base abilities and under pH 6 are usually in a state of protonation, i.e., being positively charged ( Ka ) of imidazole rings of histidine residues often reflects the overall protein catalysis functions
Link Rupa Health Editorial Team
Its small size and linear structure contribute to favorable aqueous solubility and stability under standard lyophilized storage conditions
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