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Key considerations include: Pre-existing mental health conditions may be exacerbated during weight loss Physiological changes accompanying weight loss may affect emotional stability Medication effects on gastric emptying may reduce absorption of oral medications, including oral contraceptives (requiring backup contraception after initiation and dose increases) Social and lifestyle changes during treatment create psychological stressors Clinicians should maintain awareness that mood changes during Zepbound therapy likely represent multifactorial phenomena rather than simple cause-and-effect relationships
Trends in discontinuation by indication Side effects were consistently the top reason for stopping treatment for patients receiving ADM and AOM GLP-1s
Stay hydrated aggressively, aiming for at least 64 ounces of water daily
N., Sulicz, E
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