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most comprehensive single molecule Tirzepatide, the dual agonist, produced about 20.9% weight loss at its top dose in SURMOUNT-1 ( Jastreboff et al., NEJM 2022 ) and strong glycemic control in the SURPASS program ( Fras et al., NEJM 2021 )
Serious Health Concerns: While rare, GLP1's can lead to severe conditions like acute pancreatitis, acute kidney injury, and gallbladder disease
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