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Pharmacokinetic Notes: Short-acting GLP-1 RAs (exenatide BID, lixisenatide) primarily affect postprandial glucose and tend to cause more gastrointestinal side effects initially due to rapid high peaks
Now a systematic review published Wednesday in the BMJ says its not just weight that returns after going off GLP-1s, but also concerning markers of heart disease risk
SURMOUNT-1 (Jastreboff 2022, NEJM) reported up to 20.9 percent average weight loss with tirzepatide versus 14.9 percent with semaglutide in STEP 1 (Wilding 2021, NEJM)
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