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2.2 Chronic venous insufficiency Two RDP studies on chronic venous insufficiency have shown another interesting clinical application of Pycnogenol (32, 33) that can be mechanistically explained by its beneficial effects on endothelial function and its anti-inflammatory action (65)

10.1111/joim.13422 68 TomuraS.IshizakiS.NagashimaY.ShiomiK

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Its water-soluble derivative, sodium Tan IIA sulfonate injection (STS), is widely used in the clinic as an adjuvant drug for coronary heart disease, myocardial infarction and heart failure in China [153]